1
/ Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale 131 (2014) A29–A68 A47 les classifications étaient corrélées à plusieurs indices acoustiques déterminés dans les stimuli (indices relatifs à la fréquence fonda- mentale F0, indices temporels, indices spectraux) par mesure du coefficient r de Pearson. Résultats La distance inter objet moyenne était significativement plus élevées dans le groupe des implantés cochléaires (13,1, IC 95 % :12,2–13,9) que dans le groupe des sujets normo-entendants (9,6, IC 95 % :8,1–11,2), ce qui traduit un déficit de catégorisation auditive chez les sujets implantés. Ce déficit était plus marqué dans les catégories « voix » (distance moyenne de 11,2 chez les implantés contre 6,9 chez les normo-entendants) et « musique » (distance moyenne de 13,9 chez les implantés contre 5,5 chez les normo-entendants). Malgré ce déficit, l’analyse MDS retrouvait des catégories voix et musique reproductibles chez les implantés. Nos analyses préliminaires montrent que les dimensions utilisées pour réaliser ces classifications étaient corrélées à la saillance de la fréquence fondamentale ainsi qu’à l’impulsivité dans les stimuli auditifs. Conclusion La catégorisation libre de sons naturels est un outil original permettant d’évaluer les performances auditives globales des patients implantés cochléaires. La mise en évidence des indices acoustiques préférentiellement utilisés peut avoir un impact sur les améliorations à apporter aux stratégies de codage du son. Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara- tion de conflits d’intérêts. http://dx.doi.org/10.1016/j.aforl.2014.07.125 Chirurgie cervico-faciale et cancerologie Dimanche 12 octobre 2014 14:30–16:00 Salle 252 B Sous l’égide de de la Société franc ¸ aise de carcinologie cervico-faciale Présidents de séance: B. Barry, O. Laccourreye 114 A multicenter and case-control study of human papillomavirus and laryngeal cancer in a Chinese population Y. Xu 1,, W. Jiadong 1 , D. Pin 2 , Y. Shankai 3 1 Shanghai Renji Hospital, Shanghai, China 2 Shanghai First People’s Hospital, Shanghai, China 3 Shanghai Sixth People’s Hospital, Shanghai, China Corresponding author. Substantial molecular evidence suggests a role for human papil- lomavirus (HPV) in the pathogenesis of laryngeal squamous cell carcinoma (LSCC), but epidemiologic and prognosis data have been inconsistent in a Chinese population. Matériel et méthodes: This multicenter and case control study inclu- ded 674 LSCC patients and 674 control patients treated in three centers in Shanghai from 2006 till 2013. We used immunohisto- chemistry (IHC) and GenoArray genotyping assay to evaluate the HPV infection status and determined its prevalence and influence on disease prognosis. Résultats: The total prevalence of HPV DNA was 4,9 % (33/674) in LSCC patients and 0 % (0/674) in control cases in our series (P < 0,01). HPV positive was more common in nonsmokers (13 % nonsmokers vs. 6 % somkers, P < 0,05), in nondrinkers (11 % nondrinkers vs. 6 % drinkers, P < 0,05) and in supraglottic LSCC (12 % supraglottic, 7 % glottic vs. 0 % subglottic, P < 0,05). In 33 HPV positive patients, 28 (84.8 %) were HPV-16, 2 (6.1 %) were HPV-18, and 1 (3.0 %) each HPV-31, HPV-45 and HPV-33 positive. The 3-year overall survival rate was 76.3 % for HPV positive patients and 70.7 % for HPV nega- tive patients (P = 0.30). The 3-year disease progression-free rate was 65.1 % for HPV positive patients and 58.3 % for HPV negative ones (P = 0.37). Conclusion: A very low prevalence of HPV was among LSCC patients in a Chinese population. HPV was more common in nonsmokers, non-drinkers and supraglottic LSCC patients. The presence of HPV DNA was not associated with patients’ overall survival and disease progression-free rate in our series. Disclosure of interest The authors have not supplied their decla- ration of conflict of interest. http://dx.doi.org/10.1016/j.aforl.2014.07.126 115 Observation à long terme des patients traités par crico-hyoido- épiglottopexies M. Fei Faculte de médecine, université Jiao Tong, Shanghai, China Objective To investigate the long-term results of cricohyoidoepi- glottopexy(CHEP) in the treatment of glottic carcinoma. Methods A retrospective chart review of 92 consecutive patients who underwent CHEP in the selected institut from January 1990 to December 2008. Of the 92 cases, 41 cases of stage I, 39 cases of stage II, 12 cases of stage III. The time for the decannulation and the removal of the nasal feeding and quality of phonation were used for evaluating postoperative functional rehabilitation. The esti- mated long-term survival rates were calculated by Kaplan–Meier method. Results Among 92 patients, 26 cases(27 sides) received elec- tive neck dissection and lymph nodes were pathologically positive in 3 patients(11.1 %). All final surgical margins were negative for tumor invasion. Seven patients had postoperative radiotherapy and one had chemoradiation. Thirteen patients (14.3 %) were found local recurrence and nine patients(9.7 %) had postoperative metas- tases. Overall 3-, 5-and 10-year survival rates were 90.01 %, 84.48 % and 66.93 % respectively. Cox multivariate analysis showed that the recurrence had significant influences on the overall survival rate. Conclusion CHEP not only is relatively easy to master, but also effective in the treatment of glottic carcinoma. Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara- tion de conflits d’intérêts. http://dx.doi.org/10.1016/j.aforl.2014.07.127 116 Phase 2 clinical feasibility study of a new Speaking Valve with a heat- and moisture exchanger (DualCare) for tracheotomized patients B. De kleijn , J. Wedman , B. Van der laan University Medical Center Groningen (UMCG), Groningen, Netherlands Auteur correspondant. But de la présentation Tracheotomized patients lack the function of the upper airway moisturizing, warming and filtering air. Fur- thermore they are unable to speak without occluding the cannula. Heat and Moisture Exchangers (HME) and hands-free speaking valves are developed to aid patients. The Protrach DualCare (Atos Medical, Hörby, Sweden) is the first device combining a fully func- tional HME and hands-free speaking valve for tracheotomized patients. This study is performed to determine the clinical feasi- bility of the Dualcare.

A multicenter and case-control study of human papillomavirus and laryngeal cancer in a Chinese population

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Page 1: A multicenter and case-control study of human papillomavirus and laryngeal cancer in a Chinese population

/ Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale 131 (2014) A29–A68 A47

les classifications étaient corrélées à plusieurs indices acoustiquesdéterminés dans les stimuli (indices relatifs à la fréquence fonda-mentale F0, indices temporels, indices spectraux) par mesure ducoefficient r de Pearson.Résultats La distance inter objet moyenne était significativementplus élevées dans le groupe des implantés cochléaires (13,1, IC95 % :12,2–13,9) que dans le groupe des sujets normo-entendants(9,6, IC 95 % :8,1–11,2), ce qui traduit un déficit de catégorisationauditive chez les sujets implantés. Ce déficit était plus marquédans les catégories « voix » (distance moyenne de 11,2 chez lesimplantés contre 6,9 chez les normo-entendants) et « musique »(distance moyenne de 13,9 chez les implantés contre 5,5 chezles normo-entendants). Malgré ce déficit, l’analyse MDS retrouvaitdes catégories voix et musique reproductibles chez les implantés.Nos analyses préliminaires montrent que les dimensions utiliséespour réaliser ces classifications étaient corrélées à la saillance dela fréquence fondamentale ainsi qu’à l’impulsivité dans les stimuliauditifs.Conclusion La catégorisation libre de sons naturels est un outiloriginal permettant d’évaluer les performances auditives globalesdes patients implantés cochléaires. La mise en évidence des indicesacoustiques préférentiellement utilisés peut avoir un impact sur lesaméliorations à apporter aux stratégies de codage du son.

Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara-tion de conflits d’intérêts.

http://dx.doi.org/10.1016/j.aforl.2014.07.125

Chirurgie cervico-faciale et cancerologieDimanche 12 octobre 2014 14:30–16:00Salle 252 BSous l’égide de de la Société francaise de carcinologiecervico-facialePrésidents de séance: B. Barry, O. Laccourreye

114

A multicenter and case-control studyof human papillomavirus andlaryngeal cancer in a ChinesepopulationY. Xu 1,∗, W. Jiadong 1, D. Pin 2, Y. Shankai 3

1 Shanghai Renji Hospital, Shanghai, China2 Shanghai First People’s Hospital, Shanghai, China3 Shanghai Sixth People’s Hospital, Shanghai, China∗ Corresponding author.

Substantial molecular evidence suggests a role for human papil-lomavirus (HPV) in the pathogenesis of laryngeal squamous cellcarcinoma (LSCC), but epidemiologic and prognosis data have beeninconsistent in a Chinese population.Matériel et méthodes: This multicenter and case control study inclu-ded 674 LSCC patients and 674 control patients treated in threecenters in Shanghai from 2006 till 2013. We used immunohisto-chemistry (IHC) and GenoArray genotyping assay to evaluate theHPV infection status and determined its prevalence and influenceon disease prognosis.Résultats: The total prevalence of HPV DNA was 4,9 % (33/674) inLSCC patients and 0 % (0/674) in control cases in our series (P < 0,01).HPV positive was more common in nonsmokers (13 % nonsmokersvs. 6 % somkers, P < 0,05), in nondrinkers (11 % nondrinkers vs. 6 %drinkers, P < 0,05) and in supraglottic LSCC (12 % supraglottic, 7 %glottic vs. 0 % subglottic, P < 0,05). In 33 HPV positive patients, 28(84.8 %) were HPV-16, 2 (6.1 %) were HPV-18, and 1 (3.0 %) each

HPV-31, HPV-45 and HPV-33 positive. The 3-year overall survivalrate was 76.3 % for HPV positive patients and 70.7 % for HPV nega-tive patients (P = 0.30). The 3-year disease progression-free rate was65.1 % for HPV positive patients and 58.3 % for HPV negative ones(P = 0.37).Conclusion: A very low prevalence of HPV was among LSCC patientsin a Chinese population. HPV was more common in nonsmokers,non-drinkers and supraglottic LSCC patients. The presence of HPVDNA was not associated with patients’ overall survival and diseaseprogression-free rate in our series.

Disclosure of interest The authors have not supplied their decla-ration of conflict of interest.

http://dx.doi.org/10.1016/j.aforl.2014.07.126

115

Observation à long terme despatients traités par crico-hyoido-épiglottopexiesM. FeiFaculte de médecine, université Jiao Tong, Shanghai, China

Objective To investigate the long-term results of cricohyoidoepi-glottopexy(CHEP) in the treatment of glottic carcinoma.Methods A retrospective chart review of 92 consecutive patientswho underwent CHEP in the selected institut from January 1990to December 2008. Of the 92 cases, 41 cases of stage I, 39 cases ofstage II, 12 cases of stage III. The time for the decannulation and theremoval of the nasal feeding and quality of phonation were usedfor evaluating postoperative functional rehabilitation. The esti-mated long-term survival rates were calculated by Kaplan–Meiermethod.Results Among 92 patients, 26 cases(27 sides) received elec-tive neck dissection and lymph nodes were pathologically positivein 3 patients(11.1 %). All final surgical margins were negative fortumor invasion. Seven patients had postoperative radiotherapy andone had chemoradiation. Thirteen patients (14.3 %) were foundlocal recurrence and nine patients(9.7 %) had postoperative metas-tases. Overall 3-, 5-and 10-year survival rates were 90.01 %, 84.48 %and 66.93 % respectively. Cox multivariate analysis showed thatthe recurrence had significant influences on the overall survivalrate.Conclusion CHEP not only is relatively easy to master, but alsoeffective in the treatment of glottic carcinoma.

Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara-tion de conflits d’intérêts.

http://dx.doi.org/10.1016/j.aforl.2014.07.127

116

Phase 2 clinical feasibility study of anew Speaking Valve with a heat- andmoisture exchanger (DualCare) fortracheotomized patientsB. De kleijn ∗, J. Wedman , B. Van der laanUniversity Medical Center Groningen (UMCG), Groningen,Netherlands∗ Auteur correspondant.

But de la présentation Tracheotomized patients lack the functionof the upper airway moisturizing, warming and filtering air. Fur-thermore they are unable to speak without occluding the cannula.Heat and Moisture Exchangers (HME) and hands-free speakingvalves are developed to aid patients. The Protrach DualCare (AtosMedical, Hörby, Sweden) is the first device combining a fully func-tional HME and hands-free speaking valve for tracheotomizedpatients. This study is performed to determine the clinical feasi-bility of the Dualcare.