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VIVA-LIAC 2017 Dates 29/11 AU 01/12/2017 School and meeting location : Legal and judicial pole of Bordeaux University- Pey Berland, Bordeaux Day 1: Wednesday, November 29 th 09:00 – 12:00 General assembly of LIAC participant Salle 2B 09:30 – 10:00 Reception of participant Winter School Meeting Hall 10:00 – 12:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Presentation of students - What should be achieved in this winter school Amphi 12:00 – 13:00 Lunch Winter School (only) Salle RG 13:00 Opening meeting : Thierry Couffinhal (VIVA action, Director) & Michel Spina (LIAC President) 13:00 – 17:30 CLINICAL AND EPIDEMIOLOGIC ASPECT OF VASCULAR AGING (chairmen: C. Tzourio & L. Monteiro) 13:00 – 13:45 Early vascular aging - P.M. NILSSON, Malmö - Sweden Amphi 13:45 – 14:15 Neurovascular epidemiology of aging - C. TZOURIO, Bordeaux Amphi 14:15 – 14:45 Cardiovascular epidemiology of aging - P. BOUTOUYRIE, Paris Amphi 14:45 – 15:15 Forecasted trends in disability and life expectancy - S. AHMADI-ABHARI, Liverpool - UK Amphi 15:15 – 16:00 Coffee break + poster visit Salle RG 16:00 – 16:30 Neurovascular genetic epidemiology - S. DEBETTE, Bordeaux Amphi 16:30 – 17:00 Vascular and thrombosis genetic epidemiology - D. TREGOUET, Paris Amphi 17:00 – 18:00 SELECTED ORAL PRESENTATION (Chairmen: S. Debette & J. Badaut) • Mitochondrial function regulates vascular aging in mice - K. FOOTE, Cambridge - UK • Structural imaging of the vascular wall - S. ALMAGRO, Reims • Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness - H. OBEID, Paris • Long-term trajectories of cardiometabolic risk factors in prodromal dementia: the Three-City Study - M. WAGNER, Bordeaux Amphi 18:30 – 19:30 EVENING PHILOSOPHICAL CONFERENCE ANTONIO-MARIO TAMBURRO (chairman: M. Spina) When does the vascular system age and when is there a disease? Conceptual and theoretical issues - M. LEMOINE, Tours Amphi 19:30 – 23:00 Welcome social event Wine battle Salle RG Day 2: Thursday, November 30 th 08:30 – 12:00 PATHOPHYSIOLOGIC FEATURES OF VASCULAR AGING (Chairmen: J.F. Arnal & M. Formato) 08:30 – 09:15 From physiological aging to pathological aging - J.B. MICHEL, Paris Amphi 09:15 – 09:35 Physiological models to study the human microcirculation - effects of hyperoxia - L. MONTEIRO-RODRIGUES, Lisbon - Portugal Amphi 09:35 – 09:55 Murine models for investigating vascular ageing - G. FAURY, Grenoble Amphi 09:55 – 10:55 Coffee break + poster visit Salle RG 10:55 – 11:40 New insights into vascular biology by single cell RNA sequencing - M. VANLANDEWYCK, Stockholm - Sweden Amphi 11:40 – 12:00 Thrombosis in aging - C. JAMES, Bordeaux Amphi 12:00 – 12:20 Retinal vascular imaging - C. HELMER, Bordeaux Amphi 12:30 – 14:00 Lunch + poster visit Salle RG 12:00 – 13:00 Lunch of Winter School Meeting Salle 2B 13:00 – 14:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Meet the experts - Round table with experts 14:00 – 16:00 MATRIX STRUCTURAL AND MECHANICAL STUDIES (Chairmen: I. Brunet & P. Dufourcq) Amphi 14:00 – 14:45 Model of pseudoxanthoma elasticum – Vascular calcification and aging, from gene to bedside - L. MARTIN, G. LEFTHERIOTIS, Angers 14:45 – 15:05 Vascular aging: structure and dynamics of constitutive macromolecules and sub-fragments - V. SAMOUILLAN, Toulouse Amphi 15:05 – 15:25 Tubular scaffolds for applications of vascular tissue engineering - V. LA CARRUBBA, Palermo - Italy Amphi 15:25 – 15:45 Bioprosthetic heart valve aging deterioration and age-related benefits - M. SPINA, Padova - Italy Amphi 15:45 – 16:05 Elastin modification during vascular aging and pathophysiological consequences - L. DUCA, Reims Amphi 16:05 – 16:45 Coffee break + poster visit Salle RG

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VIVA-LIAC 2017

Dates 29/11 AU 01/12/2017

School and meeting location : Legal and judicial pole of Bordeaux University- Pey Berland, Bordeaux

Day 1: Wednesday, November 29th

09:00 – 12:00 General assembly of LIAC participant Salle 2B

09:30 – 10:00 Reception of participant Winter School Meeting Hall

10:00 – 12:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Presentation of students - What should be achieved in this winter school

Amphi

12:00 – 13:00 Lunch Winter School (only) Salle RG

13:00 Opening meeting : Thierry Couffinhal (VIVA action, Director) & Michel Spina (LIAC President)

13:00 – 17:30 CLINICAL AND EPIDEMIOLOGIC ASPECT OF VASCULAR AGING (chairmen: C. Tzourio & L. Monteiro) 13:00 – 13:45 Early vascular aging - P.M. NILSSON, Malmö - Sweden Amphi

13:45 – 14:15 Neurovascular epidemiology of aging - C. TZOURIO, Bordeaux Amphi

14:15 – 14:45 Cardiovascular epidemiology of aging - P. BOUTOUYRIE, Paris Amphi

14:45 – 15:15 Forecasted trends in disability and life expectancy - S. AHMADI-ABHARI, Liverpool - UK Amphi

15:15 – 16:00 Coffee break + poster visit Salle RG

16:00 – 16:30 Neurovascular genetic epidemiology - S. DEBETTE, Bordeaux Amphi

16:30 – 17:00 Vascular and thrombosis genetic epidemiology - D. TREGOUET, Paris Amphi

17:00 – 18:00

SELECTED ORAL PRESENTATION (Chairmen: S. Debette & J. Badaut) • Mitochondrial function regulates vascular aging in mice - K. FOOTE, Cambridge - UK • Structural imaging of the vascular wall - S. ALMAGRO, Reims • Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness - H. OBEID, Paris • Long-term trajectories of cardiometabolic risk factors in prodromal dementia: the Three-City Study - M. WAGNER, Bordeaux

Amphi

18:30 – 19:30 EVENING PHILOSOPHICAL CONFERENCE ANTONIO-MARIO TAMBURRO (chairman: M. Spina) When does the vascular system age and when is there a disease? Conceptual and theoretical issues - M. LEMOINE, Tours

Amphi

19:30 – 23:00 Welcome social event Wine battle

Salle RG

Day 2: Thursday, November 30th

08:30 – 12:00 PATHOPHYSIOLOGIC FEATURES OF VASCULAR AGING (Chairmen: J.F. Arnal & M. Formato)

08:30 – 09:15 From physiological aging to pathological aging - J.B. MICHEL, Paris Amphi

09:15 – 09:35 Physiological models to study the human microcirculation - effects of hyperoxia - L. MONTEIRO-RODRIGUES, Lisbon - Portugal

Amphi

09:35 – 09:55 Murine models for investigating vascular ageing - G. FAURY, Grenoble Amphi

09:55 – 10:55 Coffee break + poster visit Salle RG

10:55 – 11:40 New insights into vascular biology by single cell RNA sequencing - M. VANLANDEWYCK, Stockholm - Sweden Amphi

11:40 – 12:00 Thrombosis in aging - C. JAMES, Bordeaux Amphi

12:00 – 12:20 Retinal vascular imaging - C. HELMER, Bordeaux Amphi

12:30 – 14:00 Lunch + poster visit Salle RG

12:00 – 13:00 Lunch of Winter School Meeting Salle 2B

13:00 – 14:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Meet the experts - Round table with experts

14:00 – 16:00 MATRIX STRUCTURAL AND MECHANICAL STUDIES (Chairmen: I. Brunet & P. Dufourcq) Amphi

14:00 – 14:45 Model of pseudoxanthoma elasticum – Vascular calcification and aging, from gene to bedside - L. MARTIN, G. LEFTHERIOTIS, Angers

14:45 – 15:05 Vascular aging: structure and dynamics of constitutive macromolecules and sub-fragments - V. SAMOUILLAN, Toulouse

Amphi

15:05 – 15:25 Tubular scaffolds for applications of vascular tissue engineering - V. LA CARRUBBA, Palermo - Italy Amphi

15:25 – 15:45 Bioprosthetic heart valve aging deterioration and age-related benefits - M. SPINA, Padova - Italy Amphi

15:45 – 16:05 Elastin modification during vascular aging and pathophysiological consequences - L. DUCA, Reims Amphi

16:05 – 16:45 Coffee break + poster visit Salle RG

16:45 – 17:45 SELECTED ORAL PRESENTATION (Chairmen: M. Laffargue & D. Henrion) • MicroRNA expressed in progenitor cells circulating in peripheral blood as prospective biomarkers of age-related macular degeneration (AMD) in its dry and wet form – preliminary data - M. KAWA, Poland • Molecular, conformational and thermal characterization of ventricular Remodeling in a pig model of tachycardia-induced cardiomyopathy - V. LLORENTE CORTES, Barcelona - Spain • Valvular calcification: implication of the Semicarbazide-Sensitive Amine Oxidase (SSAO)? - N. MERCIER, Nancy • Vascular calcification during chronic kidney disease: role of the RAGE/Cathepsin S/elastin peptides axis - A. WAHART, Reims

Amphi

17:45 – 18:15 VIVA EVENING CONFERENCE (Chairman: T. Couffinhal)

A short history of the vessel - A. BIKFALVI, Bordeaux

Amphi

20:00 Gala Diner “7ème

restaurant Panoramique – Cité du Vin”

Day 3: Friday, December 1st

08:30 – 12:15 CELL BIOLOGY AND SIGNALING (Chairwomen: C. Duplàa & V. Llorrente Cortes)

08:30 – 09:30 SELECTED ORAL PRESENTATION • Targeting Connexin40 expression or function reduces angiogenesis in the developing mouse retina - F. ALONSO, Bordeaux • Imatinib inhibits hypoxia-induced MMP-9 overexpression and activation through impairment of LRP1 and Pyk2 phosphorylation in human coronary vascular smooth muscle cells - A. BENITEZ, Barcelona - Spain • NRP1 supresses TGFβ-dependent ERK1/2 activation in endothelial cells - A. LAMPROPOULOU, London - UK • The elastin receptor complex interacts with CD36 through NEU1 and regulates oxidized LDL uptake in macrophages: potential implication in the proatherogenic effects of elastin-derived peptides - P. MAURICE, Reims • Ubiad1 promotes tumor angiogenesis by inhibiting dephosphorylation of vegfr2 in a redox dependent manner - R. SEWDUTH, Belgium

Amphi

09:30 – 10:15 Cell senescence and telomere - E. GILSON, Nice Amphi

10:15 – 10:45 Estrogens as vascular anti-ageing hormones? Experimental and clinical evidences and uncertainties - J.F. ARNAL, Toulouse

Amphi

10:45 – 11:15 Coffee break + poster visit Salle RG

11:15 – 11:45 Arteriolar and microcirculation aging - D. HENRION, Angers Amphi

11:45 – 12:15 Oxydation and inflammation in Atherosclerosis - A. LEPEDDA, Italy Amphi

12:15 – 14:00 Lunch Salle RG

12:15 – 13:00 Lunch Winter School Salle RG

13:00 – 15:00 Winter School Meeting (organizers: A. Bikfalvi & J. Badaut) Highlights and major topics identified by the students, group proposals (3 per group) for fictive/future projects and presentation

Salle 2B

14:00 – 15:00 OPEN SESSION (Chairwomen: M.A. Renault & J. Lods)

• Endothelial cell dysfunction is a new potential therapeutic target for the treatment of critical limb ischemia - C. CARADU, Pessac • Podosomes Mediate Basement Membrane Collagen-IV Proteolysis During Sprouting Angiogenesis - E. GENOT, Bordeaux •How plant food bioactives may have benefits for vascular health? The case of curcumin, L.E. MONFOULET, Lille

Amphi

15:00 Closing meeting: Thierry Couffinhal & Michel Spina