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VIVA-LIAC 2017
Dates 29/11 AU 01/12/2017
School and meeting location : Legal and judicial pole of Bordeaux University- Pey Berland, Bordeaux
Day 1: Wednesday, November 29th
09:00 – 12:00 General assembly of LIAC participant Salle 2B
09:30 – 10:00 Reception of participant Winter School Meeting Hall
10:00 – 12:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Presentation of students - What should be achieved in this winter school
Amphi
12:00 – 13:00 Lunch Winter School (only) Salle RG
13:00 Opening meeting : Thierry Couffinhal (VIVA action, Director) & Michel Spina (LIAC President)
13:00 – 17:30 CLINICAL AND EPIDEMIOLOGIC ASPECT OF VASCULAR AGING (chairmen: C. Tzourio & L. Monteiro) 13:00 – 13:45 Early vascular aging - P.M. NILSSON, Malmö - Sweden Amphi
13:45 – 14:15 Neurovascular epidemiology of aging - C. TZOURIO, Bordeaux Amphi
14:15 – 14:45 Cardiovascular epidemiology of aging - P. BOUTOUYRIE, Paris Amphi
14:45 – 15:15 Forecasted trends in disability and life expectancy - S. AHMADI-ABHARI, Liverpool - UK Amphi
15:15 – 16:00 Coffee break + poster visit Salle RG
16:00 – 16:30 Neurovascular genetic epidemiology - S. DEBETTE, Bordeaux Amphi
16:30 – 17:00 Vascular and thrombosis genetic epidemiology - D. TREGOUET, Paris Amphi
17:00 – 18:00
SELECTED ORAL PRESENTATION (Chairmen: S. Debette & J. Badaut) • Mitochondrial function regulates vascular aging in mice - K. FOOTE, Cambridge - UK • Structural imaging of the vascular wall - S. ALMAGRO, Reims • Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness - H. OBEID, Paris • Long-term trajectories of cardiometabolic risk factors in prodromal dementia: the Three-City Study - M. WAGNER, Bordeaux
Amphi
18:30 – 19:30 EVENING PHILOSOPHICAL CONFERENCE ANTONIO-MARIO TAMBURRO (chairman: M. Spina) When does the vascular system age and when is there a disease? Conceptual and theoretical issues - M. LEMOINE, Tours
Amphi
19:30 – 23:00 Welcome social event Wine battle
Salle RG
Day 2: Thursday, November 30th
08:30 – 12:00 PATHOPHYSIOLOGIC FEATURES OF VASCULAR AGING (Chairmen: J.F. Arnal & M. Formato)
08:30 – 09:15 From physiological aging to pathological aging - J.B. MICHEL, Paris Amphi
09:15 – 09:35 Physiological models to study the human microcirculation - effects of hyperoxia - L. MONTEIRO-RODRIGUES, Lisbon - Portugal
Amphi
09:35 – 09:55 Murine models for investigating vascular ageing - G. FAURY, Grenoble Amphi
09:55 – 10:55 Coffee break + poster visit Salle RG
10:55 – 11:40 New insights into vascular biology by single cell RNA sequencing - M. VANLANDEWYCK, Stockholm - Sweden Amphi
11:40 – 12:00 Thrombosis in aging - C. JAMES, Bordeaux Amphi
12:00 – 12:20 Retinal vascular imaging - C. HELMER, Bordeaux Amphi
12:30 – 14:00 Lunch + poster visit Salle RG
12:00 – 13:00 Lunch of Winter School Meeting Salle 2B
13:00 – 14:00 Winter School meeting (organizers: A. Bikfalvi & J. Badaut) Meet the experts - Round table with experts
14:00 – 16:00 MATRIX STRUCTURAL AND MECHANICAL STUDIES (Chairmen: I. Brunet & P. Dufourcq) Amphi
14:00 – 14:45 Model of pseudoxanthoma elasticum – Vascular calcification and aging, from gene to bedside - L. MARTIN, G. LEFTHERIOTIS, Angers
14:45 – 15:05 Vascular aging: structure and dynamics of constitutive macromolecules and sub-fragments - V. SAMOUILLAN, Toulouse
Amphi
15:05 – 15:25 Tubular scaffolds for applications of vascular tissue engineering - V. LA CARRUBBA, Palermo - Italy Amphi
15:25 – 15:45 Bioprosthetic heart valve aging deterioration and age-related benefits - M. SPINA, Padova - Italy Amphi
15:45 – 16:05 Elastin modification during vascular aging and pathophysiological consequences - L. DUCA, Reims Amphi
16:05 – 16:45 Coffee break + poster visit Salle RG
16:45 – 17:45 SELECTED ORAL PRESENTATION (Chairmen: M. Laffargue & D. Henrion) • MicroRNA expressed in progenitor cells circulating in peripheral blood as prospective biomarkers of age-related macular degeneration (AMD) in its dry and wet form – preliminary data - M. KAWA, Poland • Molecular, conformational and thermal characterization of ventricular Remodeling in a pig model of tachycardia-induced cardiomyopathy - V. LLORENTE CORTES, Barcelona - Spain • Valvular calcification: implication of the Semicarbazide-Sensitive Amine Oxidase (SSAO)? - N. MERCIER, Nancy • Vascular calcification during chronic kidney disease: role of the RAGE/Cathepsin S/elastin peptides axis - A. WAHART, Reims
Amphi
17:45 – 18:15 VIVA EVENING CONFERENCE (Chairman: T. Couffinhal)
A short history of the vessel - A. BIKFALVI, Bordeaux
Amphi
20:00 Gala Diner “7ème
restaurant Panoramique – Cité du Vin”
Day 3: Friday, December 1st
08:30 – 12:15 CELL BIOLOGY AND SIGNALING (Chairwomen: C. Duplàa & V. Llorrente Cortes)
08:30 – 09:30 SELECTED ORAL PRESENTATION • Targeting Connexin40 expression or function reduces angiogenesis in the developing mouse retina - F. ALONSO, Bordeaux • Imatinib inhibits hypoxia-induced MMP-9 overexpression and activation through impairment of LRP1 and Pyk2 phosphorylation in human coronary vascular smooth muscle cells - A. BENITEZ, Barcelona - Spain • NRP1 supresses TGFβ-dependent ERK1/2 activation in endothelial cells - A. LAMPROPOULOU, London - UK • The elastin receptor complex interacts with CD36 through NEU1 and regulates oxidized LDL uptake in macrophages: potential implication in the proatherogenic effects of elastin-derived peptides - P. MAURICE, Reims • Ubiad1 promotes tumor angiogenesis by inhibiting dephosphorylation of vegfr2 in a redox dependent manner - R. SEWDUTH, Belgium
Amphi
09:30 – 10:15 Cell senescence and telomere - E. GILSON, Nice Amphi
10:15 – 10:45 Estrogens as vascular anti-ageing hormones? Experimental and clinical evidences and uncertainties - J.F. ARNAL, Toulouse
Amphi
10:45 – 11:15 Coffee break + poster visit Salle RG
11:15 – 11:45 Arteriolar and microcirculation aging - D. HENRION, Angers Amphi
11:45 – 12:15 Oxydation and inflammation in Atherosclerosis - A. LEPEDDA, Italy Amphi
12:15 – 14:00 Lunch Salle RG
12:15 – 13:00 Lunch Winter School Salle RG
13:00 – 15:00 Winter School Meeting (organizers: A. Bikfalvi & J. Badaut) Highlights and major topics identified by the students, group proposals (3 per group) for fictive/future projects and presentation
Salle 2B
14:00 – 15:00 OPEN SESSION (Chairwomen: M.A. Renault & J. Lods)
• Endothelial cell dysfunction is a new potential therapeutic target for the treatment of critical limb ischemia - C. CARADU, Pessac • Podosomes Mediate Basement Membrane Collagen-IV Proteolysis During Sprouting Angiogenesis - E. GENOT, Bordeaux •How plant food bioactives may have benefits for vascular health? The case of curcumin, L.E. MONFOULET, Lille
Amphi
15:00 Closing meeting: Thierry Couffinhal & Michel Spina