UNITES DE RECHERCHE - medecine.univ-amu.fr · Bapin Luc TCH Inserm 04 86 97 73 61 Barbarat Bernadette TCH IPC 04 86 97 73 46 Bardin Florence AI Inserm 04 86 97 72 92 Barral Karine

Unité de Recherche. Centre de Recherche en Cancérologie de Marseille Mise à jour : janvier 2016 1/30

UNITÉ DE RECHERCHE UMR S 1068

Centre de Recherche en Cancérologie de Marseille DIRECTEUR : BORG Jean-Paul ADRESSE : Centre de Recherche en Cancérologie de Marseille Inserm U1068 – CNRS 7258 27 Bd Leï Roure CS 30059 13273 MARSEILLE CEDEX 09 TELEPHONE : 04 86 97 72 00 COURRIEL : [email protected] SITE WEB : http://crcm.marseille.inserm.fr/ RATTACHEMENTS : AMU - INSERM - CNRS - IPC POLES HOSPITALIERS : Institut Paoli Calmettes ECOLE DOCTORALE : Sciences de la Vie et de la Santé (ED 062) DISCIPLINES D’APPARTENANCES : DS 5 - Biologie, Médecine, Santé SPECIALITÉS : Oncologie/Immunologie GESTIONNAIRES DE L’UNITÉ : Claude ROUX / Laurence DUVIVIER


EFFECTIFS Enseignants-Chercheurs : 21 Chercheurs EPST : 53 Autres Enseignants-Chercheurs et Chercheurs : 39 BIATSS/ITA : 48 Autres BIATSS/ITA : 55 Doctorants : 57

EFFECTIFS AFFINÉS Enseignants-Chercheurs : 21 Rattachement/Tutelle

MCU AMU : 2 MCU-PH : 4 PU : 2 PU-PH : 12 PU Emérite : 1

Chercheurs EPST : 53

CR : 16 CNRS CR : 20 INSERM DR : 7 CNRS DR : 8 INSERM DR Emérite : 2 INSERM CNRS

Autres Enseignants-Chercheurs et Chercheurs : 39

PH : 6 POST-DOCTORANT : 33

BIATSS/ITA : 48

AJT : 2 INSERM TCH : 1 CNRS TCH : 11 INSERM AI : 1 AMU AI : 3 CNRS AI : 6 INSERM IE : 4 CNRS IE : 8 INSERM IR : 1 AMU IR : 3 CNRS IR : 8 INSERM

Autres BIATSS/ITA : 55

AJT CDD : 1 CNRS TCH : 1 ABSciences TCH : 17 IPC TCH CDD : 5 IPC AI CDD : 1 INSERM IE CDD : 1 AMU IE CDD : 1 CNRS IE CDD : 10 INSERM IE CDD : 1 PROTISVALOR IR CDD : 3 CNRS IR CDD : 4 INSERM IR IPC : 3 IPC ING CDD : 1 AMU ING : 1 IPC ING CDD : 1 IPC Cadre : 4 IPC

Doctorants : 57


PERSONNELS IMPLIQUÉS DANS LA RECHERCHE Nom Prénom Statut Téléphone Aboukhater Charbel Doctorant 04 86 97 72 00 Acquaviva Claire CR1 Inserm 04 86 97 72 62 Adélaïde José TCH IPC 04 91 22 33 04 Aguilera Paula Doctorante 04 86 97 74 03 Agavnian Emilie TCH IPC 04 91 22 33 33 Aimard Adrien Doctorant 04 86 97 72 00 Amouric Agnès IR CNRS CDD 04 86 97 72 00 Aragnol Denise PU 04 86 97 72 00 Arbiol Christine AI CNRS 04 86 97 72 00 Arnoulet Christine PH IPC 04 91 22 33 76 Audebert Stéphane IR IPC 04 91 22 33 07 ou 33 39 Aurrand-Lions Michel CR1 Inserm 04 86 97 72 91 Azario Françine Tech IPC 04 91 22 33 33 Azzoni Violette Doctorant 04 91 22 33 33 Baccini Michel TCH Inserm 04 86 97 72 08 Badache Ali DR2 Inserm 04 86 97 73 21 Bailly Anne-Laure Doctorant 04 86 97 72 93 Bailly Éric CR1 Inserm 04 86 97 72 57 Balzano Marielle Doctorante 04 86 97 72 93 Ballester Pedro CR1 Inserm 04 86 97 72 63 Bapin Luc TCH Inserm 04 86 97 73 61 Barbarat Bernadette TCH IPC 04 86 97 73 46 Bardin Florence AI Inserm 04 86 97 72 92 Barral Karine CR1 CNRS 04 91 82 55 81 Barthet Marc PU-PH 04 91 82 88 03 Basse Marie Jeanne AI CNRS 04 91 16 45 06 Baty Daniel DR1 CNRS 04 91 82 88 23 Baudelet Émilie AI Inserm 04 91 22 33 07 Beloribi Djefaflia Sadia Post-Doc 04 91 82 88 06 Benmansour Fatiha IE AMU CDD 04 91 82 55 81 Bertucci François PU-PH 04 91 22 47 79 Betzi Stéphane CR2 CNRS 04 86 97 73 33 Bian Benjamin TCH IPC CDD 04 91 82 88 28 Bidaut Ghislain IR2 AMU 04 86 97 73 01 Bintz Jennifer IE Inserm CDD 04 91 82 88 27 Birnbaum Daniel DR Inserm 04 91 22 33 54 Blaise Didier PU-PH 04 91 22 36 44 Blanchet Marine Doctorante 04 86 97 72 00 Blaszczak Ewa Post-Doc 04 86 97 72 00 Blazquez Roman Juan Luis Doctorant 04 86 97 72 72 Borg Jean-Paul PU-PH 04 86 97 72 51 Borge Laurence AI Inserm 04 91 82 88 16 Bouguenina Habib Doctorant 04 86 97 73 21 Bourgeas Raphaël Doctorant 04 91 16 41 28 Bourras Sarah TCH IPC CDD 04 86 97 72 76 Boutchama Henri TCH Inserm 04 86 97 73 61 ou 73 65 Boyer Jean-Baptiste IE Inserm CDD 04 91 22 33 07 Brenet Fabienne CR1 Inserm 04 86 97 72 82 Bressy Christian Post-Doc CDD 04 91 82 88 15 Bricker Mickael AJT Inserm 04 86 97 73 61 ou 73 65 Brunel Jean-Michel CR1 CNRS 04 86 13 68 30 Cabaud Olivier IE Inserm 04 86 97 72 64


Calmels Boris PH IPC 04 91 22 34 41 Camoin Luc IR Inserm 04 86 97 72 58 Capel Arnaud TCH Inserm 04 86 97 73 62 Carbuccia Nadine AI Inserm 04 91 22 34 08 Carrier Alice CR1 CNRS 04 91 82 88 29 Cartier-Michaud Amandine Post-Doc 04 86 97 72 93 Castellano Rémy IR IPC 04 86 97 73 32

Castro-Cruz Monica Del Carmen Doctorante 04 86 97 72 00

Cervera Nathalie TCH IPC 04 91 22 33 04 Chabannon Christian PU 04 91 22 34 41 Chaffanet Max Cadre IPC 04 91 22 34 77 Chames Patrick CR1 CNRS 04 91 82 88 33 Chanez Brice Doctorant 04 86 97 72 00 Charafe-Jauffret Emmanuelle PU-PH 04 91 22 35 09 Chaves De Lima Daniel Doctorant 04 86 97 72 00 Chetrit Bernard IE CNRS 04 86 97 72 07 Chevrier Véronique IR1 Inserm 04 86 97 72 64 Chrabaszcz Elodie Doctorant 04 86 97 72 00 Chretien Anne-Sophie Post-Doc 04 86 97 73 41 Churikov Dmitri Ing IPC CDD 04 86 97 72 00 Cisa Sabina Doctorant 04 86 97 72 85 Cohen Romy Doctorant 04 91 82 88 33 Colazet Magali Doctorant 04 91 82 88 34 Collette Yves DR2 Inserm 04 86 97 73 31 Combes Sébastien MCU AMU 04 91 28 82 91 Coppin Émilie Doctorant 04 86 97 72 74 Corda Yves CR1 CNRS 04 86 97 72 00 Coulier François CR1 Inserm 04 86 97 72 07 Coulon Stéphane CR1 CNRS 04 86 97 72 00 Courtier Frédéric Doctorant 04 91 22 41 21 Da Costa Quentin IE Inserm CDD 04 86 97 73 03 Dang Cao Cuong Post-Doc 04 86 97 72 00 Daulat Avais Post-Doc 04 86 97 72 55 David Guido PU Emérite 04 86 97 72 51 Defaye Arnaud IR Inserm CDD 04 91 82 88 33 De Grandis Maria Post-Doc 04 86 97 72 93 De la Roche Saint André Christophe CR1 CNRS 04 86 97 72 00 De Melo Abi Doctorant 04 86 97 73 92 De Sepulveda Paulo CR1 Inserm 04 86 97 72 85 Del Bano Joanie Doctorant 04 91 82 88 34 Degos Clara Post-Doc 04 86 97 73 41 Dehe Pierre-Marie CR1 Inserm 04 86 97 72 00 Derviaux Carine Doctorant 04 86 97 73 31 Drivet Elsa Doctorant 04 86 97 73 31 Dubreuil Patrice DR1 Inserm 04 86 97 72 81 Duprez Estelle DR2 CNRS 04 86 97 73 11 Dusetti Nelson DR2 Inserm 04 91 82 88 28 Duvivier Laurence AI Inserm 04 86 97 72 04 Egea Antonio Post-Doc 04 86 97 72 53 El Kaoutari Samad IE Inserm CDD 04 86 97 73 03 Fares Joanna Post-Doc 04 86 97 73 52 Farina Anne IE Protisvalor CDD 04 86 97 72 00 Fauriat Cyril CR2 Inserm 04 86 97 73 47 Fenaux Gregory IE Inserm CDD 04 86 97 72 82 Ferrier Valérie Cadre IPC 04 91 22 33 52


Finetti Pascal TCH IPC 04 91 22 33 04 Fourquet Patrick IE CNRS 04 91 22 33 07 Fraisier Christophe Post-Doc 04 91 82 88 28 Fuchs Robert DR Emérite 04 86 97 72 00 Fujii Shingo IR CNRS 04 86 97 72 00 Gaillard Pierre-Henri DR2 CNRS 04 86 97 72 00 Garcia Stéphane PU-PH 04 91 82 88 22 Garcia Valérie CR1 CNRS 04 86 97 74 12 Garcin Edwige Post-Doc 04 86 97 73 92 Garnier Séverine Ing IPC 04 91 22 33 33 Garzino Patrick TCH Inserm 04 86 97 73 62 Gayet Odile IE Inserm 04 91 82 88 27 Géli Vincent DR1 CNRS 04 86 97 72 00 Gelsi-Boyer Véronique MCU-PH 04 91 22 41 75 Ghossoub Rania Post-Doc 04 86 97 73 52 Gibier Patrick IE Inserm 04 86 97 73 62 Ginestier Christophe CR1 Inserm 04 91 22 35 09 Gonçalvès Anthony PU-PH 04 91 22 33 11 Gondois-Rey Françoise IR2 Inserm 04 86 97 72 76 Goubard Armelle TCH IPC CDD 04 86 97 73 32 Gouirand Victoire Doctorante 04 91 82 88 06 Granjeaud Samuel IR1 Inserm 04 86 97 73 01 Gros Abigaëlle IE Inserm CDD 04 91 22 35 09 Guasch Géraldine CR1 Inserm 04 86 97 72 00 Guenneau-Puvirajesinghe Tania Post-Doc 04 86 97 72 55 Guerrin-Paillet Mathilde Doctorant 04 86 97 72 00 Guervilly Jean-Hugues CR2 Inserm 04 86 97 72 00 Guillaumond Fabienne Post-Doc 04 91 82 88 06 Guille Arnaud TCH IPC 04 91 22 33 04 Hirsch Ivan DR2 Emérite 04 86 97 72 71 Hoffer Laurent Post-Doc 04 86 97 73 35 Houvenaeghel Gilles PU-PH 04 91 22 33 33 Imjeti Naga Sailaja Post-Doc 04 86 97 73 52 Iovanna Juan DR1 Inserm 04 91 82 88 03 Isnardon Daniel Cadre IPC 04 86 97 73 64 Isogawa Asako IR CNRS 04 86 97 72 00 Josselin Emmanuelle IE Inserm 04 86 97 72 63 Jourquin Frédéric IE CNRS 04 86 97 72 00 Jover Sylvie TCH CNRS 04 86 97 72 03 Just-Landi Sylvaine TCH IPC 04 86 97 73 45 Khan Muntaz Post-Doc 04 86 97 72 00 Karaki Sara Doctorant 04 86 97 72 66 Kashyap Rudra Doctorant 04 86 97 73 52 Kerfelec Brigitte CR1 CNRS 04 91 82 88 33 Koubi Myriam Doctorant 04 86 97 73 12 Lac Sophie IE Inserm CDD 04 91 82 88 15 Ladaique Amandine Doctorante 04 86 97 72 00 Laloum Laurence TCH Inserm 04 86 97 72 02 Lambaudie Eric PH IPC 04 91 22 33 33 Launay Hélène IR CNRS CDD 04 86 97 72 00 Laureti Luisa Post-Doc 04 86 97 73 81 Leblanc Raphaël Post-Doc 04 86 97 73 52 Leca Julie Doctorant 04 91 82 88 36 Lecocq Éric TCH Inserm 04 86 97 72 84 Lembo Frédérique TCH IPC CDD 04 86 97 73 52


Lequeue Charlotte Doctorante 04 86 97 72 72 Létard Sébastien TCH ABSciences 04 86 97 72 82 Lhoumeau Anne-Catherine MCU-PH 04 86 97 72 54 Livrati Philippe TCH IPC 04 86 97 73 45 Llorente Bertrand CR1 CNRS 04 86 97 72 00 Loncle Céline IR IPC 04 91 82 88 15 Lopez Almeida Léonor Doctorante 04 86 97 72 53 Lopez Isabelle AJT CNRS CDD 04 86 97 73 61 Lopez Marc IR Inserm 04 86 97 72 61 Lopez Sophie IR Inserm 04 86 97 72 83 Lopresti Alexia Doctorante 04 86 97 72 00 Luciano Pierre CR1 CNRS 04 86 97 72 00 Machu Christophe IE CNRS CDD 04 86 97 74 05 Maestroni Laetitia IR CNRS CDD 04 86 97 72 00 Mailhac Camille Doctorant 04 91 82 88 34 Malenfant Carine TCH IPC 04 91 22 34 46 Malissen Nausicaa Doctorante 04 86 97 72 00 Mallet Françoise TCH IPC 04 86 97 73 44 Mamessier Emilie CR1 Inserm 04 91 22 33 33 Manai Marwa Doctorant 04 91 22 33 33 Mancini Stéphane CR1 Inserm 04 86 97 72 91 Mangon Aurélie Doctorant 04 86 97 73 21 Marchetto Sylvie IR2 Inserm 04 86 97 72 53 Maroc Christine TCH IPC 04 91 22 33 33 Martinez Sébastien Doctorant 04 86 97 72 52 Marty Jean-Baptiste TCH IPC CDD 04 86 97 73 52 Maslowska Katarzyna Post-Doc 04 86 97 72 00 Matmati Samah Doctorante 04 86 97 72 00 Maurin Pauline Doctorant 04 86 97 72 53 Maya-Milles Douglas Post-Doc 04 86 97 72 00 Menck Kerstin Post-Doc 04 86 97 72 00 Milhas Sabine Doctorante 04 86 97 72 00 Modesti Mauro DR2 CNRS 04 86 97 72 00 Molejon Maria Inès Post-doc 04 91 82 88 00 Montersino Camille Ing AMU CDD 04 86 97 73 32 Morelli Xavier DR2 CNRS 04 86 97 73 31 Morin Stéphanie Doctorante 04 86 97 73 74 Mosca Cyndie IE Inserm CDD 04 86 97 72 84 Mozziconacci Marie-Joëlle PH IPC 04 91 22 33 77 Murati Anne PH IPC 04 91 22 41 75 Nguyen Dang Tan Doctorant 04 86 97 72 00 Nguyen Lia IE Inserm CDD 04 86 97 73 22 Nigri Jérémy IE Inserm CDD 04 91 82 88 15 Nino Suarez Carlos Post-Doc 04 86 97 72 00 Normanno Davide IR2 CNRS 04 86 97 73 91 Nunès Jacques DR2 Inserm 04 86 97 72 74 Olive Daniel PU PH 04 86 97 72 71 Olivier Bruno ATP2 Inserm 04 91 82 88 29 Orlanducci Florence TCH IPC 04 86 97 73 44 Orsoni Jean-Christophe TCH Inserm 04 86 97 73 62 Pages Vincent CR1 CNRS 04 86 97 72 00 Pasero Christine Post-Doc 04 86 97 73 47 Pastor Sonia IE Inserm 04 86 97 72 76 Péon Lopez Antonio Post-Doc 04 86 97 74 21 Philippin Gaëlle IE CNRS 04 86 97 72 00 Platet Nadine IR2 Inserm 04 86 97 73 12


Pophillat Matthieu IE Inserm 04 86 97 72 59 Poplineau Mathilde Post-Doc 04 86 97 73 12 Préau Véronique TCH Inserm 04 91 82 88 00 Raux Brigitt Doctorant 04 86 97 73 33 Rebuffet Etienne IR Inserm CDD 04 86 97 73 35 Receveur-Bréchot Véronique DR2 CNRS 04 91 16 45 01 Restouin Audrey TCH IPC 04 86 97 73 32 Rey Jérôme PH IPC 04 91 22 33 33 Rocchi Palma CR1 Inserm 04 86 97 72 67 Roche Philippe CR1 CNRS 04 91 16 45 06 Roques Julie AI CDD Inserm 04 91 82 88 06 Roux Claude IE Inserm 04 86 97 72 05 Rovere-Reiss Julie TCH IPC 04 86 97 72 01 Rubis Marion AI AMU 04 86 97 72 93 Saccone Marjorie Doctorante 04 91 82 88 05 Saez Ayala Magali IR Inserm CDD 04 86 97 72 00 Salaun Danièle AI Inserm 04 86 97 73 21 Santoni Marie-Josée CR1 CNRS 04 86 97 72 56 Sari Karim TCH Inserm 04 91 82 88 29 Scaglione Sarah AI CNRS 04 86 97 72 00 Sebbagh Michaël CR1 Inserm 04 86 97 72 57 Semenchenko Kostyantyn Post-Doc 04 86 97 72 52 Sergé Arnauld MCU-PH 04 86 97 72 92 Simon Marie-Noëlle CR1 CNRS 04 86 97 72 00 Sonongbua Ying Doctorant 04 86 97 73 40 Soubeyran Philippe CR1 Inserm 04 91 82 88 07 Soucie Erinn CR1 Inserm 04 86 97 72 83 Spoto Patricia TCH Inserm 04 91 82 88 29 Swayden Mirna Doctorante 04 91 82 88 07 Tadi Satish Post-Doc 04 86 97 73 92 Taha Mohammed Doctorant 04 86 97 72 00 Taieb David MCU-PH 04 86 97 72 67 Takedachi Arato Post-Doc 04 86 97 72 00 Termine Elise IE2 Inserm 04 91 82 88 33 Thibult Marie-Laure Cadre IPC 04 86 97 73 63 Thuault Sylvie MCU AMU 04 86 97 73 22 Tisserand Julie Doctorant 04 86 97 72 83 Toiron Yves TCH IPC 04 86 97 72 53 Tomasini Richard CR1 Inserm 04 91 82 88 15 Tournaire Roselyne MCU AMU 04 91 82 88 05 Valdenaire Simon Doctorant 04 86 97 72 00 Vandevelde Amelle Doctorante 04 86 97 73 12 Van Hiel Boris Doctorant 00 00 00 00 00 Vasseur Sophie CR1 Inserm 04 91 82 88 06 Verdier-Pinard Pascal CR1 Inserm 04 86 97 73 21 Vernerey Julien IR Inserm CDD 04 86 97 73 12 Vey Norbert PU-PH 04 91 22 37 54 Viens Patrice PU-PH 04 91 22 37 78 Wagner Monica Doctorante 04 86 97 72 00 Walton Alexandra Doctorante 04 86 97 72 00 Wicinski Julien TCH IPC 04 91 22 34 08 Xerri Luc PU-PH 04 91 22 34 57 Zhang Hongshan Doctorant 04 86 97 72 00 Zhang Xu Doctorant 04 86 97 72 66 Zidi Bochra Doctorante 04 86 97 72 00 Zimmermann Pascale DR2 Inserm 04 86 97 73 51


PERSONNELS AVEC HDR Nom Prénom Statut Aragnol Denise PU Aurrand-Lions Michel CR1 Inserm Badache Ali DR2 Inserm Barthet Marc PU-PH Baty Daniel DR1 CNRS Bertucci François PU-PH Birnbaum Daniel DRE Inserm Blaise Didier MD – PU-PH Borg Jean-Paul PU-PH Brunel Jean-Michel CR1 CNRS Calmels Boris PH IPC Camoin Luc IRE Inserm Carrier Alice CR1 CNRS Chabannon Christian PU Chaffanet Max Cadre IPC Chames Patrick CR1 CNRS Charafe-Jauffret Emmanuelle PU-PH Collette Yves DR2 Inserm Coulier François CR1 Inserm Coulon Stéphane CR1 CNRS De la Roche Saint André Christophe CR1 CNRS De Sepulveda Paulo CR1 Inserm Dubreuil Patrice DR1 Inserm Duprez Estelle DR2 CNRS Dusetti Nelson DR2 Inserm Fuchs Robert DRCE CNRS Gaillard Pierre-Henri DR2 CNRS Garcia Stéphane PH-PU Géli Vincent DR1 CNRS Gonçalvès Anthony PH Hirsch Ivan DR2 Inserm Houvenaegel Gilles PU-PH Iovanna Juan DR1 Inserm Kerfelec Brigitte CR1 CNRS Llorente Bertrand CR1 CNRS Lopez Marc IRE Inserm Mancini Stéphane CR1 Inserm Modesti Mauro DR2 CNRS Mozziconacci Marie-Joëlle PH Nunès Jacques DR2 Inserm Olive Daniel PU-PH Pagès Vincent CR1 CNRS Receveur-Brechot Véronique DR2 CNRS Rocchi Palma CR1 Inserm Roche Philippe CR1 CNRS Santoni Marie-Josée CR1 CNRS Simon Marie-Noëlle CR1 CNRS Soubeyran Philippe CR1 Inserm Soucie Erinn CR1 Inserm Taieb David MCU-PH Tomasini Richard CR1 Inserm Tournaire Roselyne MCU


Verdier-Pinard Pascal CR1 Inserm Vey Norbert PU-PH Viens Patrice PU-PH Xerri Luc PU-PH Zimmermann Pascale DR2 Inserm

EQUIPES DE RECHERCHE ET THEMATIQUES EQUIPE : E1 - Molecular Oncology RESPONSABLE : BIRBAUM Daniel EQUIPE : E2 - Cell Polarity, Signaling and Cancer RESPONSABLE : BORG Jean-Paul EQUIPE : E3 - Signaling, Hematopoiesis and Mechanism of Oncogenesis RESPONSABLE : DUBREUIL Patrice EQUIPE : E4 - Molecular Mechanisms of Tumor Cell Migration RESPONSABLE : BADACHE Ali EQUIPE : E5 - Junctional Adhesion Molecules in Tumour/host Interactions RESPONSABLE : AURRAND-LIONS Michel EQUIPE : E6 - Epigenetic Factors in Normal and Malignant Hematopoiesis RESPONSABLE : DUPREZ Estelle EQUIPE : E7 - Spatio-Temporal Regulation of Cell Signaling - Scaffolds & Phosphoinositides RESPONSABLE : ZIMMERMANN Pascale EQUIPE : E8 - Cell stress RESPONSABLE : IOVANNA Juan EQUIPE : E9 - DNA Damage Tolerance RESPONSABLE : FUCHS Robert EQUIPE : E10 - Telomeres and Chromatin RESPONSABLE : GELI Vincent EQUIPE : E11 - Homologous Recombination, NHEJ and Maintenance of Genomic Integrity RESPONSABLE : MODESTI Mauro EQUIPE : E12 - Structure-Specific Endonucleases and Genome Stability RESPONSABLE : GAILLARD Pierre-Henri EQUIPE : E13 - Genome Dynamics and Recombination RESPONSABLE : LLORENTE Bertrand EQUIPE : E14 - Immunity & Cancer RESPONSABLE : OLIVE Daniel EQUIPE : E15 - Integrative Structural & Chemical Biology RESPONSABLES : COLLETTE Yves & MORELLI Xavier EQUIPE : E16 - Antibody Therapeutics & Immunotargeting RESPONSABLES : BATY Daniel & CHAMES Patrick EQUIPE : E17 - Computational Biology & Drug Design RESPONSABLE : BALLESTER Pedro


PERSONNELS PAR EQUIPE DE RECHERCHE

EQUIPE : E1 - Molecular Oncology RESPONSABLE : BIRBAUM Daniel

EQUIPE : E2 - Cell Polarity, Signaling and Cancer

RESPONSABLE : BORG Jean-Paul

Bailly Éric Borg Jean-Paul Boyer Jean-Baptiste Daulat Avais Fourquet Patrick Gonçalvès Anthony Guenneau-Puvirajesinghe Tania Guerrin-Paillet Mathilde Ladaique Amandine Lhoumeau Anne-Catherine Lopez Almeida Léonor

Acquaviva Claire Adélaïde José Aimard Adrien Azzoni Violette Bertucci François Birnbaum Daniel Cabaud Olivier Carbuccia Nadine Cervera Nathalie Chaffanet Max Charafe-Jauffret Emmanuelle Chevrier Véronique Courtier Frédéric Finetti Pascal Garnier Séverine Gelsi-Boyer Véronique Ginestier Christophe Gros Abigaëlle Guasch Géraldine Guille Arnaud Houvenaeghel Gilles Josselin Emmanuelle Karaki Sara Lambaudie Eric Launay Simon Lopez Marc Lopresti Alexia Mamessier Emilie Manaï Marwa Mozziconacci Marie-Joëlle Murati Anne Nguyen Dang Tan Rocchi Palma Taieb David Valdenaire Simon Viens Patrice Wicinski Julien


Marchetto Sylvie Martinez Sébastien Maurin Pauline Santoni Marie-Josée Sebbagh Michaël Semenchenko Kostyantyn Toiron Yves Wagner Monica Walton Alexandra Audebert Stéphane Baudelet Émilie Camoin Luc Pophillat Matthieu

EQUIPE : E3 - Signaling, Hematopoiesis and Mechanism of Oncogenesis

RESPONSABLE : DUBREUIL Patrice

Brenet Fabienne Cisa Sabina De Sepulveda Paulo Dubreuil Patrice Fénaux Grégory Lecocq Éric Létard Sébastien Lopez Sophie Mosca Cyndie Soucie Erinn Tisserand Julie

EQUIPE : E4 - Molecular Mechanisms of Tumor Cell Migration

RESPONSABLE : BADACHE Ali

Badache Ali Bouguenina Habib Chanez Brice Mangon Aurélie Nguyen Lia Salaun Danièle Thuault Sylvie Verdier-Pinard Pascal

EQUIPE : E5 - Junctional Adhesion Molecules in Tumour/host Interactions

RESPONSABLE : AURRAND-LIONS Michel

Aurrand-Lions Michel Balzano Marielle Bardin Florence Bailly Anne-Laure Cartier-Michaud Amandine De Grandis Maria Mancini Stéphane Rubis Marion Sergé Arnauld


EQUIPE : E6 - Epigenetic Factors in Normal and Malignant Hematopoiesis RESPONSABLE : DUPREZ Estelle

Calmels Boris Chabannon Christian Duprez Estelle Koubi Myriam Platet Nadine Poplineau Mathilde Vandevelve Amelle Vernerey Julien Zidi Bochra

EQUIPE : E7 - Spatio-Temporal Regulation of Cell Signaling - Scaffolds & Phosphoinositides

RESPONSABLE : ZIMMERMANN Pascale

Castro-Cruz Monica Del Carmen David Guido Egea Antonio Fares Joanna Ghossoub Rania Kashyap Rudra Imjeti Naga Sailaja Leblanc Raphaël Lembo Frédérique Menck Kerstin Van Hiel Boris Zimmermann Pascale

EQUIPE : E8 - Cell stress

RESPONSABLE : IOVANNA Juan

Barthet Marc Beloribi Djefaflia Sadia Bian Benjamin Bintz Jennifer Borge Laurence Bressy Christian Carrier Alice Dusetti Nelson Fraisier Christophe Garcia Stéphane Gayet Odile Gouirand Victoire Guillaumond Fabienne Iovanna Juan Lac Sophie Leca Julie Loncle Céline Molejon Maria Inès Nigri Jérémy Olivier Bruno Roques Julie Saccone Marjorie Sari Karim Soubeyran Philippe Spoto Patricia


Swayden Mirna Tomasini Richard Tournaire Roselyne Vasseur Sophie

EQUIPE : E9 - DNA Damage Tolerance

RESPONSABLE : FUCHS Robert

Chrabaszcz Elodie Fuchs Robert Fujii Shingo Isogawa Asako Laureti Luisa Maslowska Katarzyna Pages Vincent Philippin Gaelle

EQUIPE : E10 - Telomeres and Chromatin

RESPONSABLE : GELI Vincent

Aguilera Paula Aragnol Denise Churikov Dmitri Corda Yves Coulon Stéphane De la Roche Saint André Christophe Géli Vincent Jourquin Frédéric Luciano Pierre Machu Christophe Maestroni Laetitia Matmati Samah Maya-Milles Douglas Nino Suarez Carlos Simon Marie-Noëlle

EQUIPE : E11 - Homologous Recombination, NHEJ and Maintenance of Genomic Integrity

RESPONSABLE : MODESTI Mauro

Chaves De Lima Daniel De Melo Abi Garcin Edwige Modesti Mauro Normanno Davide Tadi Satish Zhang Hongshan

EQUIPE : E12 - Structure-Specific Endonucleases and Genome Stability

RESPONSABLE : GAILLARD Pierre-Henri

Blaszczak Ewa Dehe Pierre-Marie Gaillard Pierre-Henri Guervilly Jean-Hugues Scaglione Sarah Takedachi Arato


EQUIPE : E13 - Genome Dynamics and Recombination RESPONSABLE : LLORENTE Bertrand

Arbiol Christine Garcia Valérie Khan Muntaz Llorente Bertrand

EQUIPE : E14 - Immunity & Cancer

RESPONSABLE : OLIVE Daniel

Aboukhater Charbel Arnoulet Christine Barbarat Bernadette Blaise Didier Blazquez-Roman Juan-Luis Bourras Sarah Chretien Anne-Sophie Coppin Émilie Degos Clara Fauriat Cyril Gondois-Rey Françoise Hirsch Ivan Just-Landi Sylvaine Lequeue Charlotte Livrati Philippe Malissen Nausicaa Mallet Françoise Morin Stéphanie Nunès Jacques Olive Daniel Orlanducci Florence Pasero Christine Pastor Sonia Rey Jérôme Sonongbua Ying Taha Mohammed Vey Norbert Xerri Luc

EQUIPE : E15 - Integrative Structural & Chemical Biology

RESPONSABLES : COLLETTE Yves & MORELLI Xavier

Amouric Agnès Barral Karine Basse Marie jeanne Benmansour Fatiha Betzi Stéphane Blanchet Marine Bourgeas Raphaël Brunel Jean Michel Castellano Rémy Chetrit Bernard Collette Yves Combes Sébastien Derviaux Carine Drivet Elsa


Goubard Armelle Hoffer Laurent Milhas Sabine Montersino Camille Morelli Xavier Raux Brigitt Rebuffet Etienne Receveur-Bréchot Véronique Restouin Audrey Saez Ayala Magali Roche Philippe Zhang Xu

EQUIPE : E16 - Antibody Therapeutics & Immunotargeting

RESPONSABLES : BATY Daniel & CHAMES Patrick

Baty Daniel Chames Patrick Cohen Romy Colazet Magali Defaye Arnaud Del Bano Joanie Kerfelec Brigitte Mailhac Camille Termine Elise

EQUIPE : E17 - Computational Biology & Drug Design

RESPONSABLES : Pedro BALLESTER

Ballester Pedro Dang Cuong Cao Peon Lopez Antonio

EQUIPE : E18 – SERVICES COMMUNS

Agavnian Emilie Azario Francine Baccini Michel Bapin Luc Bidaut Ghislain Boutchama Henri Bricker Mickael Capel Arnaud Coulier François Da Costa Quentin Duvivier Laurence El Kaoutari Samad Farina Anne Ferrier Valerie Garzino Patrick Granjeaud Samuel Gibier Patrick Isnardon Daniel Jover Sylvie Laloum Laurence Lopez Isabelle Malenfant Carine


ACCUEIL MASTERS Master Pathologie Humaine – Oncologie : 18 Master Développement et Immunologie : 5 Master Bioinformatique, Biochimie Structurale et Génomique : 3 Master Pathologie Humaine - Génétique Humaine et Médicale : 2 Master Biosciences : 1 Master Biochimie Structurale Protéomique Métabolomique : 1

THESES DE DOCTORAT ANNÉE 2014

Wilfried TRAORE « Erbin, une protéine de la polarité impliquée dans la

physiopathologie mammaire » 12/06/2014

Julien PELTIER

« Recherche et validation de marqueurs protéiques du cancer colorectal dans les fluides biologiques par des approches de protéomique

différentielle »

20/06/2014

Marc TURINI

« Développement d’anticorps bispécifiques pour le

traitement de cancers du sein réfractaires à l’action du

trastuzumab »

27/06/2014

Xu ZHANG

“Study of protein-protein complexes involving the low molecular weight chaperone

Hsp27 ; implications in prostate cancer”

03/09/2014

Hassnae AFRACHE

« Prédiction de la fonction des butyrophilines par l'étude de

leur évolution et de leur variabilité génétique »

10/10/2014

Raynier DEVILLIER

« Caractérisation moléculaire des leucémies aiguës

myéloïdes avec dysmyélopoïèse »

31/10/2014

Kahina HAMMAM

« Nouveau concept de resensibilisation à la

chimiothérapie en activant la nucléoside kinase dCK par le masitinib, un inhibiteur de

protéines tyrosine kinases »

24/11/2014

Damien NEVOLTRIS

« Les anticorps à domaine unique: une nouvelle source de biosenseurs et de modulateurs

allostériques pour les récepteurs membranaires »

26/11/2014

Maroc Christine Marty Jean-Baptiste Orsoni Jean-Christophe Préau Véronique Roux Claude Rovere-Reiss Julie Thibult Marie-Laure


Mignane KA « Immunorègulation dans la

fièvre Q: le rôle des molécules de cosignalisation »

01/12/2014

Imène YAHIAOUI « L’analyse de l’activation de la

voie P13K/AKT dans le lymphome folliculaire »

11/12/2014

Marion SALVADOR

« La régulation épigénétique des cellules souches

cancéreuses mammaires : un nouveau rôle pour l'ARN non-

codant Xist »

16/12/2014

Javier CELIS-GUTIERREZ

« Influence des protéines de signalisation, Dok-1 et Dok-2

sur le devenir et le comportement des cellules

Natural Killer »

17/12/2014

David BIRNBAUM « Altérations moléculaires dans

l’adénocarcinome du pancréas »

19/12/2014

CONTRATS ANNÉE 2014

-ANR 2014 : Ali Badache Exploration structurale et fonctionnelle de la partie C-terminale intrinsèquement désordonnée de ErbB2 -AMIDEX interdisciplinaire 2014: Mauro Modesti: ‘Light innovative methodologies for molecular interaction and signaling analysis in biology’ -ANR 2014: Bertrand Llorente: Chromosome dynamics and recombination during meiosis -ANR 2014: Pierre-Henri Gaillard: EMI1PHOSUMO -ANR 2014: Vincent Géli : QuiescenceDNA -AMIDEX interdisciplinaire 2014: Tania Guenneau-Puvirajesinghe ‘Bio-Cloaking with Graphene and Metamaterials’ -ANR 2014: Vincent Pagès: GENOBLOCK: Mechanisms of error-free lesion tolerance -ANR 2014: Shingo Fujii: MUTA-K7: Genetic variability in prokaryotes: characterization of a novel mutagenesis-cassette -AMIDEX innovation 2014: Pascale Zimmermann: PDZ targeting hits cancer communication -ARC 2014: Pascale Zimmermann: Pertinence des exosomes syntenine dans l'oncogénèse et le micro-environnement tumoral -ARC 2014 : Géraldine Guasch : Régulation des cellules souches cancéreuses des épithéliums de transition par leur niche -ARC 2014 : Jean-Paul Borg : Role of the MINK1-PRICKLE1 complex in the tumorigenic program -GEFLUC 2014: Daniel Birnbaum : La médecine personnalisée appliquée aux cancers du sein -GEFLUC 2014: Ali Badache : Analyse multiparamétrique de la migration des cellules tumorales pilotée par une station microfluidique -INCa PLBIO 2014 : Ali Badache : Structural investigation of protein-protein interactions directing iASPP oncogenic functions


-INCa PLBIO 2014 : Jean-Paul Borg : Molecular study and targeting of the Wnt/PCP VANGL2 receptor in breast cancer -Association Marie-Do 2014: François Bertucci: Analyse génomique des couples tumeur primaire/métastase dans le cancer du sein: CGH array et séquençage ciblé -IMBE 2014 : Anthony Goncalves : Recherche d'un toximètre biologique: étude de validation analytique chez des patientes atteintes d'un cancer du sein en situation adjuvante – FREEMALLPIG -PHRC 2014 : François Bertucci : COCABIO: comparison of biological features between pNO triple negative breast cancer tumors with size<= 10mm (pTa/b) versus pT1c T2>=30mm Projet Canceropôle PACA 2014 (J.-P. Borg) « Génération d’une souris déficiente pour PTK7 » Cancéropôle PACA 2014 (N Vey) Evaluation des effets secondaires tardifs chez les jeunes adultes traités pour leucémie aiguë Mars 2014- Sept 2016-ITMO-cancer (E Duprez, partner team), appel d’offre épigénétique en partenariat avec l’IGR TransEpiLe ARC 2014: Involvement of FES kinases in cell transformation ARC 2014 (S. Mancini équipe M Aurrand-Lions) ARC 2014 : Jacques Nunès : DOK tumor supressor genes in chronic myelomonocytic leukemia Fondation pour la Recherche médicale : Labellisation de l’équipe Daniel Olive : 2014 : projet molécules de cosignalisation Ligue Nationale contre le Cancer 2014: Renouvellement de la labellisation de l’équipe de Patrice Dubreuil INCa PLBIO : Patrice Dubreuil (partner team) : Deregulation de la methylation de l'ADN dans l'hematopoiese GEFLUC 2014 : Estelle Duprez : Impact d’un nouveau marqueur épigénétique sur la réponse aux traitements des cellules de leucémies aiguës myéloïdes GEFLUC 2014 : Michel Aurrand-Lions : Hétérogénéité des cellules souches leucémiques dans la Leucémie Aiguë Myéloïde: étude génomique en cellule unique Canceropole PACA émergence : Fabienne Brenet : Aspects épigénétiques et métaboliques de la coopération oncogénique dans les pathologies tumorales dépendantes de cKit. Clinical trial EFFIKIR 2014 (Daniel Olive, partner team) Clinical trial AZA-LDE 2014 (Yves Collette) Clinical trial GFM-VORAZA 2014 (Yves Collette) Clinical trial GSK 2014: Etude de phase I/II d'immunothérapie par la protéine recWT1-A10+-AS01B après greffe allogénique de cellules souches hématopoïétiques chez des patients porteurs d'une hémopathie myéloïde exprimant le gène WT1. (Daniel Olive/Didier Blaise) Clinical trial 2014 PTK7 Genosciences (Yves Collette)


Clinical trial 2014 AMGEN : Identification of clinical and biological prognostic factors for acute myeloid Servier 2014: partnership Dart-antiCD123 project: Daniel Olive/Yves Collette Innate Pharma 2014 : Daniel Olive : effet de nouveaux anticorps sur LAM et lymphomes “Role of Dclk1 expressing cells in the initiation and the progression of intestinal and pancreatic tumors” J. Iovanna (CRCM) INCa 2014 “Therapeutic targeting of glycolysis in cancer”. Sophie Vasseur. Cancéropôle PACA 2014. “Mitochondrial function at the center of cancer cells”. Alice Carrier. Cancéropôle PACA 2014. “Inhibition of the immunosuppressive effect of cancer cells: a therapeutic strategy for the treatment of pancreatic cancer.” Nelson Dusseti. Cancéropôle PACA 2014. Chaire d’Excellence AMIDEX: ‘The search for new predictive biomarkers of PDAC drug response and prognosis from molecular profiling and clinical data’. Pedro Ballester “Le fonctionnement mitochondrial au centre des cellules cancéreuses et de leur microenvironnement ». Alice Carrier. Gefluc 2014

BREVETS ANNÉE 2014 -M Aurrand-Lions: ANTAGONISTS OF GRASP55 FOR USE AS A MEDICAMENT -J.-P. Borg et al. Brevet EP13305409.8 « METHODS AND PHARMACEUTICALS COMPOSITIONS FOR TREATING BREAST CANCERS ». -Estelle Duprez: EP14305672.9.NEW BIOMARKER FOR AML -Aurrand-Lions M: EP15305471.3 - NEW BIOMARKER FOR OUTCOME IN AML; US2013309252 (A1) -Duconseil P, Gilabert M, Gayet O, Loncle C, Moutardier V, Turrini O, Calvo E, Ewald J, Giovannini M, Gasmi M, Bories E, Barthet M, Ouaissi M, Goncalves A, Poizat F, Raoul JL, Secq V, Garcia S, Viens P, Iovanna J and Dusetti N. (December 8, 2014): Methods, Kits and compositions for phenotyping pancreatic ductal adenocarcinoma behavior by transcriptomics.

-R Tomasini, J Iovanna, V Secq, S Garcia.: Identification du complexe ROBO1/SLIT2 comme cible thérapeutique contre le cancer pancréatique et le traitement des douleurs neuropathiques associées.

-Guillaumond F, Iovanna JL, Vasseur S. (December 18, 2014): New method for treating pancreatic carcinoma. »

-Tomasini R, Iovanna J, Secq V, Garcia S. Method and pharmaceutical composition for inhibiting neuronal remodeling (EP13306690.2).


PUBLICATIONS ANNÉE 2014 140 publications

Acunzo,J., Andrieu, C., Baylot, V., and Rocchi, P. Hsp27 as a Therapeutic Target in Cancers. Curr Drug Targets. 2014; 15:423-431.

Acunzo,J., Baylot, V., So, A., and Rocchi, P. TCTP as therapeutic target in cancers. Cancer Treat Rev. 2014; 40:760-769.

Adenis,A., Blay, J. Y., Bui-Nguyen, B., Bouche, O., Bertucci, F., Isambert, N., Bompas, E., Chaigneau, L., Domont, J., Ray-Coquard, I., Blesius, A., Van Tine, B. A., Bulusu, V. R., Dubreuil, P., Mansfield, C. D., Acin, Y., Moussy, A., Hermine, O., and Le Cesne, A. Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: A randomized controlled open-label trial. Ann Oncol. 2014; 25:1762-1769.

Arcangeli,M.L., Bardin, F., Frontera, V., Bidaut, G., Obrados, E., Adams, R. H., Chabannon, C., and Aurrand-Lions, M. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells. 2014; 32:1043-1054.

Asbagh,L.A., Vazquez, I., Vecchione, L., Budinska, E., De Vriendt, V., Baietti, M. F., Steklov, M., Jacobs, B., Hoe, N., Singh, S., Imjeti, N. S., Zimmermann, P., Sablina, A., and Tejpar, S. The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling. Oncotarget. 2014; 5:10070-10083.

Ballester,P.J., Schreyer, A., and Blundell, T. L. Does a more precise chemical description of protein-ligand complexes lead to more accurate prediction of binding affinity? J Chem Inf Model. 2014; 54:944-955.

Bertucci,F., Finetti, P., Viens, P., and Birnbaum, D. EndoPredict Predicts for the response to neoadjuvant chemotherapy in ER-positive, HER2-negative breast cancer. Cancer Lett. 2014; 355:70-75.

Bertucci,F., Ueno, N. T., Finetti, P., Vermeulen, P., Lucci, A., Robertson, F. M., Marsan, M., Iwamoto, T., Krishnamurthy, S., Masuda, H., Van, D. P., Woodward, W. A., Cristofanilli, M., Reuben, J. M., Dirix, L., Viens, P., Symmans, W. F., Birnbaum, D., and Van Laere, S. J. Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival. Ann Oncol. 2014; 25:358-365.

Bertucci,F., Finetti, P., Vermeulen, P., Van Dam, P., Dirix, L., Birnbaum, D., Viens, P., and Van Laere, S. Genomic profiling of inflammatory breast cancer: A review. Breast. 2014; 23:538-545.

Bibi,S., Langenfeld, F., Jeanningros, S., Brenet, F., Soucie, E., Hermine, O., Damaj, G., Dubreuil, P., and Arock, M. Molecular Defects in Mastocytosis: KIT and Beyond KIT. Immunol Allergy Clin North Am. 2014; 34:239-262.

Birol,M., Enchev, R. I., Padilla, A., Stengel, F., Aebersold, R., Betzi, S., Yang, Y., Hoh, F., Peter, M., Dumas, C., and Echalier, A. Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer. PLoS ONE. 2014; 9:e105688-

Bojarczuk,K., Siernicka, M., Dwojak, M., Bobrowicz, M., Pyrzynska, B., Gaj, P., Karp, M., Giannopoulos, K., Efremov, D. G., Fauriat, C., Golab, J., and Winiarska, M. B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies. Leukemia. 2014; 28:1163-1167.

Bolla,J.M. and Brunel, J. M. Enhancing antibiotic activity to combat resistant Gram-negative bacteria: what's next? Future Med Chem. 2014; 6:1849-1851.

Bonacci,T., Audebert, S., Camoin, L., Baudelet, E., Bidaut, G., Garcia, M., Witzel, I. I., Perkins, N. D., Borg, J. P., Iovanna, J. L., and Soubeyran, P. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. J Proteome Res. 2014; 13:2478-2494.


Bontems,F., Fish, R. J., Borlat, I., Lembo, F., Chocu, S., Chalmel, F., Borg, J. P., Pineau, C., Neerman-Arbez, M., Bairoch, A., and Lane, L. C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. PLoS ONE. 2014; 9:e86476-

Bornet,O., Nouailler, M., Feracci, M., Sebban-Kreuzer, C., Byrne, D., Halimi, H., Morelli, X., Badache, A., and Guerlesquin, F. Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase. FEBS Letters. 2014; 588:2031-2036.

Bouvet,M., Lugari, A., Posthuma, C. C., Zevenhoven, J. C., Bernard, S., Betzi, S., Imbert, I., Canard, B., Guillemot, J. C., Lecine, P., Pfefferle, S., Drosten, C., Snijder, E. J., Decroly, E., and Morelli, X. Coronavirus Nsp10: a Critical Co-Factor for Activation of Multiple Replicative Enzymes. Journal of Biological Chemistry. 2014; 289:25783-25796.

Bouvin-Pley,M., Morgand, M., Moreau, A., Meyer, L., Goujard, C., Mouquet, H., Nussenzweig, M. C., Pace, C. S., Ho, D. D., Bjorkman, P. J., Baty, D., Chames, P., Pancera, M., Kwong, P. D., Poignard, P., Barin, F., and Braibant, M. Adaptation of HIV-1 Envelope Glycoprotein gp120 to Humoral Immunity over the Course of the Epidemic. AIDS Res Hum Retroviruses. 2014; 30:A224-

Bouvin-Pley,M., Morgand, M., Meyer, L., Goujard, C., Moreau, A., Mouquet, H., Nussenzweig, M., Pace, C., Ho, D., Bjorkman, P. J., Baty, D., Chames, P., Pancera, M., Kwong, P. D., Poignard, P., Barin, F., and Braibant, M. Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies. J Virol. 2014; 88:13910-13917.

Brecqueville,M., Rey, J., Devillier, R., Guille, A., Gillet, R., Adelaide, J., Gelsi-Boyer, V., Arnoulet, C., Chaffanet, M., Mozziconacci, M. J., Vey, N., Birnbaum, D., and Murati, A. Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase. Haematologica. 2014; 99:37-48.

Brisson L, Pouyet L, N'guessan P, Garcia S, Lopes N, Warcollier G, Iovanna JL, Carrier A. The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4(+) T Cells. Cell Rep. 2015 Jan 6;10(1):39-46.

Bulai Livideanu,C., Pouplard, C., Laurent, C., Tournier, E., Laharrague, P., Apoil, P. A., Eischen, M., Dubreuil, P., Hermine, O., Lamant, L., and Paul, C. Mastocytoses systémiques avec taux de tryptase inférieur à 20 ug. Ann Dermatol Venereol. 2014; 141:S277-

Calvo,E., Grzenda, A., Lomberk, G., Mathison, A., Iovanna, J., and Urrutia, R. Single and combinatorial chromatin coupling events underlies the function of transcript factor kruppel-like factor 11 in the regulation of gene networks. BMC Mol Biol. 2014; 15:10-

Candelli,A., Holthausen, J. T., Depken, M., Brouwer, I., Franker, M. A., Marchetti, M., Heller, I., Bernard, S., Garcin, E. B., Modesti, M., Wyman, C., Wuite, G. J., and Peterman, E. J. Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution. Proc Natl Acad Sci U S A. 2014; 111:15090-15095.

Cano,C.E., Hamidi, T., Garcia, M. N., Grasso, D., Loncle, C., Garcia, S., Calvo, E., Lomberk, G., Dusetti, N., Bartholin, L., Urrutia, R., and Iovanna, J. L. Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis. GUT. 2014; 63:984-995.

Celis-Gutierrez,J., Boyron, M., Walzer, T., Pandolfi, P. P., Jonjic, S., Olive, D., Dalod, M., Vivier, E., and Nunes, J. A. Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014; 33:1928-1940.

Cervera,N., Itzykson, R., Coppin, E., Prebet, T., Murati, A., Legall, S., Vey, N., Solary, E., Birnbaum, D., and Gelsi-Boyer, V. Gene mutations differently impact the prognosis of the myelodysplastic and myeloproliferative classes of chronic myelomonocytic leukemia. Am J Hematol. 2014; 89:604-609.


Chaix,A., Arcangeli, M. L., Lopez, S., Voisset, E., Yang, Y., Vita, M., Letard, S., Audebert, S., Finetti, P., Birnbaum, D., Bertucci, F., Aurrand-Lions, M., Dubreuil, P., and De Sepulveda, P. KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570. Oncogene. 2014; 3:872-881.

Chaluvally-Raghavan,P., Zhang, F., Pradeep, S., Hamilton, M. P., Zhao, X., Rupaimoole, R., Moss, T., Lu, Y., Yu, S., Pecot, C. V., Aure, M. R., Peuget, S., Rodriguez-Aguayo, C., Han, H. D., Zhang, D., Venkatanarayan, A., Krohn, M., Kristensen, V. N., Gagea, M., Ram, P., Liu, W., Lopez-Berestein, G., Lorenzi, P. L., Borresen-Dale, A. L., Chin, K., Gray, J., Dusetti, N. J., McGuire, S. E., Flores, E. R., Sood, A. K., and Mills, G. B. Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell. 2014; 26:863-879.

Champelovier,P., Barbier, P., Daras, E., Douillard, S., Toussaint, B., Persoon, V., Curri, V., Peyrot, V., and Combes, S. The Indolylcoumarin Coufin Exhibits Potent Activity Against Renal Carcinoma Cells without Affecting Hematopoietic System. Anticancer Agents Med Chem. 2014; 14:862-871.

Chauvot de Beauchene,I., Allain, A., Panel, N., Laine, E., Trouve, A., Dubreuil, P., and Tchertanov, L. Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity. PLoS Comput Biol. 2014; 10:e1003749-

Chretien,A.S., Le Roy, A., Vey, N., Prebet, T., Blaise, D., Fauriat, C., and Olive, D. Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity. Front Immunol. 2014; 5:122-

Churikov,D., Charifi, F., Simon, M. N., and Geli, V. Rad59-facilitated acquisition of y' elements by short telomeres delays the onset of senescence. PLoS Genet. 2014; 10:e1004736-

Comeau,A.M., Arbiol, C., and Krisch, H. M. Composite conserved promoter-terminator motifs (PeSLs) that mediate modular shuffling in the diverse T4-like myoviruses. Genome Biol Evol. 2014; 6:1611-1619.

Contesto-Richefeu,C., Tarbouriech, N., Brazzolotto, X., Betzi, S., Morelli, X., Burmeister, W. P., and Iseni, F. Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit d4 in complex with the a20 N-terminal domain. PLoS Pathog. 2014; 10:e1003978-

Coppin,E., Gelsi-Boyer, V., Morelli, X., Cervera, N., Murati, A., Pandolfi, P. P., Birnbaum, D., and Nunes, J. A. Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML). Leukemia. 2014;

Cornen,S., Guille, A., Adelaide, J., Addou-Klouche, L., Finetti, P., Saade, M. R., Manai, M., Carbuccia, N., Bekhouche, I., Letessier, A., Raynaud, S., Charafe-Jauffret, E., Jacquemier, J., Spicuglia, S., de The, H., Viens, P., Bertucci, F., Birnbaum, D., and Chaffanet, M. Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling. PLoS ONE. 2014; 9:e81843-

Cowan,J.E., McCarthy, N. I., Parnell, S. M., White, A. J., Bacon, A., Serge, A., Irla, M., Lane, P. J., Jenkinson, E. J., Jenkinson, W. E., and Anderson, G. Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive alphabetaT Cells in the Adult Thymus. J Immunol. 2014; 193:1204-1212.

Damaj,G., Joris, M., Chandesris, O., Hanssens, K., Soucie, E., Canioni, D., Kolb, B., Durieu, I., Gyan, E., Livideanu, C., Cheze, S., Diouf, M., Garidi, R., Georgin-Lavialle, S., Asnafi, V., Lhermitte, L., Lavigne, C., Launay, D., Arock, M., Lortholary, O., Dubreuil, P., and Hermine, O. ASXL1 but Not TET2 Mutations Adversely Impact Overall Survival of Patients Suffering Systemic Mastocytosis with Associated Clonal Hematologic Non-Mast-Cell Diseases. PLoS ONE. 2014; 9:e85362-

Daou,P., Hasan, S., Breitsprecher, D., Baudelet, E., Camoin, L., Audebert, S., Goode, B. L., and Badache, A. Essential and non-redundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration. Mol Biol Cell. 2014; 25:658-668.


De Bellis,F., Carafa, V., Conte, M., Rotili, D., Petraglia, F., Matarese, F., Francoijs, K. J., Ablain, J., Valente, S., Castellano, R., Goubard, A., Collette, Y., Mandoli, A., Martens, J. H., de Thé, H., Nebbioso, A., Mai, A., Stunnenberg, H. G., and Altucci, L. Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392. Cancer Res. 2014; 74:2328-2339.

de Thonel,A., Hazoume, A., Kochin, V., Isoniemi, K., Jego, G., Fourmaux, E., Hammann, A., Mjahed, H., Filhol, O., Micheau, O., Rocchi, P., Mezger, V., Eriksson, J. E., Rangnekar, V. M., and Garrido, C. Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. Cell Death Dis. 2014; 5:e1016-

Decaup,E., Duault, C., Bezombes, C., Poupot, M., Savina, A., Olive, D., and Fournie, J. J. Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVgamma9 gammadelta T lymphocytes. Immunol Lett. 2014; 161:133-137.

Deng,L., Shang, L., Bai, S., Chen, J., He, X., Trevino, R. M., Chen, S., Li, X., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T. K., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S., and Liu, S. microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res. 2014; 74:6648-6660.

Duconseil,P., Gilabert, M., Gayet, O., Loncle, C., Moutardier, V., Turrini, O., Calvo, E., Ewald, J., Giovannini, M., Gasmi, M., Bories, E., Barthet, M., Ouaissi, M., Goncalves, A., Raoul, J. L., Secq, V., Garcia, S., Viens, P., Iovanna, J., and Dusetti, N. Transcriptome analysis predicts clinical outcome and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma. Pancreatology. 2014; 14:s66-s67.

Eischen,M., Paul, C., Bernard, J., Laurent, C., Dubreuil, P., Laharrague, P., Evrard, S., Apoil, P. A., Lamant, L., Espinosa, E., Tavitian, S., Pouplard, C., Hermine, O., Laroche, M., and Bulai Livideanu, C. Fractures osseuses dans la mastocytose: analyse d'une cohorte de patients. Ann Dermatol Venereol. 2014; 141:S277-S278.

El Helou,R., Wicinski, J., Guille, A., Adelaide, J., Finetti, P., Bertucci, F., Chaffanet, M., Birnbaum, D., Charafe-Jauffret, E., and Ginestier, C. A distinct DNA methylation signature defines breast cancer stem cells and predicts cancer outcome. Stem Cells. 2014; 32:3031-3036.

Even-Desrumeaux,K., Nevoltris, D., Lavaut, M. N., Alim, K., Borg, J. P., Audebert, S., Kerfelec, B., Baty, D., and Chames, P. Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display. Mol Cell Proteomics. 2014; 13:653-665.

Fanale,D., Iovanna, J. L., Calvo, E. L., Berthezene, P., Belleau, P., Dagorn, J. C., Bronte, G., Cicero, G., Bazan, V., Rolfo, C., Santini, D., and Russo, A. Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility? Expert Opin Ther Targets. 2014; 18:841-850.

Fauriat,C. and Olive, D. AML drug resistance: c-Myc comes into play. Blood. 2014; 123:3528-3530.

Finetti,P., Guille, A., Adelaide, J., Birnbaum, D., Chaffanet, M., and Bertucci, F. ESPL1 is a candidate oncogene of luminal B breast cancers. Breast Cancer Res Treat. 2014; 147:51-59.

Fortugno,P., Josselin, E., Tsiakas, K., Agolini, E., Cestra, G., Teson, M., Santer, R., Castiglia, D., Novelli, G., Dallapiccola, B., Kurth, I., Lopez, M., Zambruno, G., and Brancati, F. Nectin-4 Mutations Causing Ectodermal Dysplasia with Syndactyly Perturb the Rac1 Pathway and the Kinetics of Adherens Junction Formation. J Invest Dermatol. 2014; 134:2146-2153.

Fraisier,C., Papa, A., Granjeaud, S., Hintzen, R., Martina, B., Camoin, L., and Almeras, L. Cerebrospinal Fluid Biomarker Candidates Associated with Human WNV Neuroinvasive Disease. PLoS ONE. 2014; 9:e93637-


Fraisier,C., Rodrigues, R., Hai, V. V., Belghazi, M., Bourdon, S., Paranhos-Baccala, G., Camoin, L., Almeras, L., and Peyrefitte, C. N. Hepatocyte pathway alterations in response to in vitro Crimean Congo hemorrhagic fever virus infection. Virus Res. 2014; 179:187-230.

Fraisier,C., Koraka, P., Belghazi, M., Bakli, M., Granjeaud, S., Pophillat, M., Lim, S. M., Osterhaus, A., Martina, B., Camoin, L., and Almeras, L. Kinetic Analysis of Mouse Brain Proteome Alterations Following Chikungunya Virus Infection before and after Appearance of Clinical Symptoms. PLoS ONE. 2014; 9:e91397-

Frykholm,K., Alizadehheidari, M., Fritzsche, J., Wigenius, J., Modesti, M., Persson, F., and Westerlund, F. Probing Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels. Small. 2014; 10:884-887.

Garcia,M., Finetti, P., Bertucci, F., Birnbaum, D., and Bidaut, G. Detection of driver protein complexes in breast cancer metastasis by large-scale transcriptome-interactome integration. Methods Mol Biol. 2014; 1101:67-85.

Garcia,M.N., Grasso, D., Lopez-Millan, M. B., Hamidi, T., Loncle, C., Tomasini, R., Lomberk, G., Porteu, F., Urrutia, R., and Iovanna, J. L. IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation. J Clin Invest. 2014; 124:4709-4722.

Gayet,O., Loncle, C., Duconseil, P., Gilabert, M., Lopez, M. B., Moutardier, V., Turrini, O., Calvo, E., Ewald, J., Giovannini, M., Gasmi, M., Bories, E., Barthet, M., Ouaissi, M., Goncalves, A., Poizat, F., Raoul, J. L., Secq, V., Garcia, S., Viens, P., Dusetti, N., and Iovanna, J. A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor. Oncotarget. 2014;

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